Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
نویسندگان
چکیده
منابع مشابه
Leukemia inhibitory factor determines the growth status of injured adult sensory neurons.
Conditioning injury to adult mammalian sensory neurons enhances their regeneration potential. Here we show that leukemia inhibitory factor (LIF) is a fundamental component of the conditioning response. Conditioning injury in vivo significantly increases the intrinsic growth capacity of sensory neurons in vitro from LIF+/+ mice. This conditioning effect is significantly blunted in sensory neuron...
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Peripheral nerve section promotes regenerative, elongated neuritic growth of adult sensory neurons. Although the role of chloride homeostasis, through the regulation of ionotropic GABA receptors, in the growth status of immature neurons in the CNS begins to emerge, nothing is known of its role in the regenerative growth of injured adult neurons. To analyze the intracellular Cl- variation after ...
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The density and binding properties of receptors for nerve growth factor (NGF) in normal and injured sensory neurons have been analyzed by quantitative radioautography following incubation of tissue sections with radioiodinated NGF. The technique is designed to study binding sites that are half-maximally saturated by picomolar concentrations of NGF: Additional sites of lower affinity have not be...
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Although some sensory ganglion cells in mature animals are catecholaminergic, most mammalian sensory neurons that express the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) do so only transiently during early gangliogenesis in vivo. The lack of TH expression at later stages appears to be due to modulation of this catecholaminergic potential. A previous study showed that the phenoty...
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We have studied the effects of NGF on the chemosensitivity of adult rat DRG neurons over a 1-2 week period in vitro, using voltage-clamp and radioactive ion flux methods. A sustained proton evoked current was reversibly lost in NGF-free medium after 1 week. Proton-evoked efflux of radioactive 86Rb+ ions was also depressed in NGF deprived cultures, although depolarization with 40 mM potassium st...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2001
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.21-18-07161.2001